Robust Tests for Single-marker Analysis in Case-Control Genetic Association Studies
نویسندگان
چکیده
منابع مشابه
Title Robust Tests for Case-control Genetic Association Studies
May 10, 2010 Type Package Title Robust tests for case-control genetic association studies Version 1.03 Date 2010-05-10 Author Yong ZANG , Wingkam FUNG , Gang ZHENG Maintainer Yong ZANG Depends R (>= 2.6.0), mvtnorm Description This package supplies several robust tests for case-control genetic association studies. The te...
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Genome-wide association studies (GWAs) have identified thousands of DNA loci associated with a variety of traits. Statistical inference is almost always based on single marker hypothesis tests of association and the respective p-values with Bonferroni correction. Since commercially available genomic arrays interrogate hundreds of thousands or even millions of loci simultaneously, many causal ye...
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In genetic studies of complex diseases, the underlying mode of inheritance is often not known. Thus, the most powerful test or other optimal procedure for one model, e.g. recessive, may be quite inefficient if another model, e.g. dominant, describes the inheritance process. Rather than choose among the procedures that are optimal for a particular model, it is preferable to see a method that has...
متن کاملPackage 'rassoc' Title Robust Tests for Case-control Genetic Association Studies
November 6, 2009 Type Package Title Robust tests for case-control genetic association studies Version 1.01 Date 2009-11-06 Author Yong ZANG , Wingkam FUNG , Gang ZHENG Maintainer Yong ZANG Depends R (>= 2.6.0), mvtnorm Description This package supplies several robust tests for case-control genetic association studies. T...
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Genome-wide association studies (GWASs) aim to genotype enough single nucleotide polymorphisms (SNPs) to effectively capture common genetic variants across the genome. Even though the number of SNPs genotyped in such studies can exceed a million, there is still interest in testing association with SNPs that were not genotyped in the study sample. Analyses of such untyped SNPs can assist in sign...
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ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 2009
ISSN: 0003-4800,1469-1809
DOI: 10.1111/j.1469-1809.2009.00506.x